Hubungan Antara Infeksi Menular Seksual dengan Kanker Reproduksi pada Wanita Usia Subur
DOI:
https://doi.org/10.32528/tijhs.v17i1.3499Keywords:
sexually transmitted infections, reproductive cancer, Human Papillomavirus, cervical cancer, cancer screeningAbstract
Kanker reproduksi pada wanita merupakan masalah kesehatan masyarakat yang signifikan,
dengan infeksi menular seksual (IMS) sebagai faktor risiko utama. Hubungan antara Infeksi
Menular Seksual (IMS) dan kanker reproduksi melalui Human Papilloma Virus (HPV) telah
banyak diteliti, namun penelitian pada populasi tertentu masih memerlukan penelitian lebih
lanjut. Tujuan: Menganalisis hubungan antara riwayat infeksi menular seksual dengan
kejadian kanker reproduksi pada wanita. Penelitian cross-sectional dilakukan pada 82
penderita kanker reproduksi di RSUD AWS Samarinda periode Januari-Juni 2024. Teknik
purposive sampling dalam penelitian ini menggunakan kriteria inklusi penderita kanker
payudara atau reproduksi yang dikonfirmasi histopatologi dan berusia ≥18 tahun. Data
dikumpulkan melalui wawancara terstruktur menggunakan kuesioner tervalidasi (Cronbach's
alpha 0,85). Analisis menggunakan uji Chi-square dengan tingkat signifikansi α = 0,05.
Mayoritas responden berusia 46-55 tahun (40,2%) dengan pendidikan SMA (40,2%).
Sebanyak 46 responden (56,1%) mengalami kanker reproduksi dan 36 responden (43,9%)
kanker payudara. Riwayat IMS ditemukan pada 17 responden (20,7%), dengan 14 orang
(82,4%) mengalami kanker reproduksi. Analisis menunjukkan hubungan signifikan antara
riwayat IMS dengan jenis kanker (p-value = 0,014; OR = 0,208; 95% CI: 0,054-0,792), yang
menunjukkan bahwa riwayat IMS lebih sering ditemukan pada penderita kanker reproduksi
dibandingkan dengan kanker payudara. Terdapat hubungan signifikan antara riwayat infeksi
menular seksual (IMS) dengan jenis kanker pada penderita kanker reproduksi. Mayoritas
responden dengan riwayat IMS mengalami kanker reproduksi, mengkonfirmasi hubungan
etiologis yang kuat. Temuan ini memperkuat pentingnya program skrining kanker serviks,
edukasi kesehatan reproduksi, dan vaksinasi HPV
References
Cermak, M., Cottrell, R., & Murnan, J. (2010). Women’s knowledge of HPV and their perceptions of physician educational efforts regarding HPV and cervical cancer. Journal of Community Health, 35(3). https://doi.org/10.1007/s10900-010-9232-y
Gazzetta, S., Valent, F., Sala, A., Driul, L., & Brunelli, L. (2024). Sexually transmitted infections and the HPV-related burden: evolution of Italian epidemiology and policy. Frontiers in Public Health, 12. https://doi.org/10.3389/fpubh.2024.1336250
Hamar, B., Teutsch, B., Hoffmann, E., Hegyi, P., Váradi, A., Nyirády, P., Hunka, Z., Ács, N., Lintner, B., Hermánné, R. J., & Melczer, Z. (2023). Trichomonas vaginalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta‐analysis of 470 000 patients. International Journal of Gynecology & Obstetrics, 163(1), 31–43. https://doi.org/10.1002/ijgo.14763
Hewavisenti, R. V., Arena, J., Ahlenstiel, C. L., & Sasson, S. C. (2023). Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk. In Frontiers in Immunology (Vol. 14). https://doi.org/10.3389/fimmu.2023.1112513
Jodjana, M. S., Windiani, I. G. A. T., Adnyana, I. G. A. N. S., Pratiwi, N. L. S., & Soetjiningsih. (2023). Knowledge regarding cervical cancer and HPV vaccination in adolescent girls. Intisari Sains Medis, 14(1). https://doi.org/10.15562/ism.v14i1.1668
Kawata, K., & Koga, H. (2020). Sexually transmitted infections and cervical cancer: Knowledge and prevention awareness among female university students in Japan. Nursing Open, 7(4). https://doi.org/10.1002/nop2.488
Klein, J. M. A., Runge, I., Pannen, A.-K., Wakuma, T., Abera, S. F., Adissie, A., Unverzagt, S., Schmitt, M., Waterboer, T., Höfler, D., Thomssen, C., & Kantelhardt, E. J. (2024). Prevalence of bacterial vaginosis, sexually transmitted infections and their association with HPV infections in asymptomatic women attending antenatal care in Ethiopia. Ecancermedicalscience, 18. https://doi.org/10.3332/ecancer.2024.1783
Leite, F. M. C., Amorim, M. H. C., Primo, C. C., & Gigante, D. P. (2017). Violence against women and cervical cancer screening: a systematic review. In Journal of Clinical Nursing (Vol. 26, Issues 15–16). https://doi.org/10.1111/jocn.13328
Markowitz, L. E., & Schiller, J. T. (2021). Human Papillomavirus Vaccines. Journal of Infectious Diseases, 224. https://doi.org/10.1093/infdis/jiaa621
Muntyanu, A., Nechaev, V., Pastukhova, E., Logan, J., Rahme, E., Netchiporouk, E., Zubarev, A., & Litvinov, I. V. (2022). Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study. The Lancet Regional Health - Europe, 20. https://doi.org/10.1016/j.lanepe.2022.100454
Peitsidis, P., Kalmantis, K., Peitsidou, A., Zervoudis, S., Papaspyrou, I., Georgoulias, N., & Kioses, E. (2012). Chlamydial infection in female lower genital tract and its correlation with cervical smear abnormalities. Bratislava Medical Journal, 113(6). https://doi.org/10.4149/bll_2012_081
Rout, R. R., Das, R., Madhavi, C., Mohapatra, J., Tiwari, H. D., & Parhad, P. (2022). Prevalence of trichomonas vaginalis and candida species among women of reproductive age group. International Journal of Health Sciences. https://doi.org/10.53730/ijhs.v6ns5.8823
Stewart, J., Bukusi, E., Celum, C., Delany-Moretlwe, S., & Baeten, J. M. (2020). Sexually transmitted infections among African women: An opportunity for combination sexually transmitted infection/HIV prevention. In AIDS (Vol. 34, Issue 5). https://doi.org/10.1097/QAD.0000000000002472
Teshale, G., Jejaw, M., Demissie, K. A., Baykemagn, N. D., Yehuala, T. Z., & Kelkay, J. M. (2025). Healthcare-Seeking behavior for sexually transmitted infections among women who initiated sexual intercourse at an early age in 22 Sub-Saharan African Countries: a multilevel analysis of 2018–2024 demographic and health survey data. BMC Infectious Diseases, 25(1), 734. https://doi.org/10.1186/s12879-025-11138-4
Downloads
Published
Issue
Section
License
Copyright (c) 2025 pipit feriani

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.